By Elio Riboli (auth.), Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione (eds.)
This booklet contains lawsuits from the 3rd overseas convention on Advances in nutrients and melanoma, held in Naples in might 2012. This hugely multidisciplinary assembly analyzed “nutrition and melanoma” from varied views and at the foundation of targeted and updated experimental methods. wisdom at the relation among way of life, nutrition, and melanoma is explored in a few contributions, and the position of nutritional intervention in melanoma sufferers is mentioned. problems with very important curiosity to the study group, similar to epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of motion of traditional compounds within the diet), obtain special attention. one more key subject is the rising molecular applied sciences (the “omics”) which could solid mild at the interaction among food and human malignancies. Chapters take the shape of stories that come with sections providing professional opinions.
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Extra resources for Advances in Nutrition and Cancer
Dunlap SM, Chiao LJ, Nogueira L, Usary J, Perou CM, Varticovski L, Hursting SD (2012) Obesity enhances epithelial-to-mesenchymal transition, cancer stem cell enrichment, and tumor progression in a novel Wnt-1 mammary cancer model. Cancer Prev Res 15 May (Epub ahead of print) 61. DeLellis K, Ingles S, Kolonel L, McKean-Cowdin R, Henderson B, Stanczyk F et al (2003) IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort. Br J Cancer 88:277–282 62. Baglietto L, English DR, Hopper JL, Morris HA, Tilley WD, Giles GG (2007) Circulating insulin-like growth factor-I and binding protein-3 and the risk of breast cancer.
In addition, to provide flexibility, certain characteristics of the evidence were used to upgrade or downgrade conclusions. The conclusions provided the basis for making recommendations, and the recommendations were based only on the conclusions for which the likely causality was judged probable or convincing. The second expert report features eight general and two special recommendations (Table 1). The recommendations have a broad-based approach for public health purposes; they are formulated as advice on foods and diets for the prevention of cancer as a whole rather than on specific nutrients and particular cancer sites.
Zappia et al. 1007/978-3-642-38007-5_2, Ó Springer-Verlag Berlin Heidelberg 2014 21 22 S. D. Hursting Abbreviations AMPK BMI CR COX-2 DIO EMT FGF-2 IGF-1 JAK mTOR MCP-1 NF-kB PAI-1 PI3K STAT TNF-a tPA uPA VEGF ZEB1 AMP-activated kinase Body mass index Caloric restriction Cyclooxygenase-2 Diet-induced obesity Epithelial-to-mesenchymal transition Fibroblast growth factor-2 Insulin-like growth factor-1 Janus kinase Mammalian target of rapamycin Monocyte chemoattractant protein-1 Nuclear factor kappa-light-chain-enhancer of activated B cells Plasminogen activator inhibitor-1 Phosphatidylinositol 3-kinase Signal transducer activator of transcription Tumor necrosis factor-alpha Tissue-type plasminogen activators Urokinase-type plasminogen activators Vascular endothelial growth factor Zinc finger E-box-binding homeobox 1 Contents 1 Introduction...........................................................................................................................